Ursodeoxycholic acid for intrahepatic cholestasis in pregnancy
نویسندگان
چکیده
منابع مشابه
Intrahepatic cholestasis of pregnancy: changes in maternal-fetal bile acid balance and improvement by ursodeoxycholic acid.
Intrahepatic cholestasis of pregnancy (ICP) is a disease characterized by generalized pruritus and biochemical cholestasis that appears typically during the last trimester of gestation. The most predictive and accurate markers for diagnosis and follow-up of ICP are increased total bile acid levels (above 11,0 micromol/L), enhanced cholic acid percentage (above 42%) and decreased glycine/taurine...
متن کاملursodeoxycholic acid and s-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy: a meta-analysis
conclusions udca decreased the pruritus score, tba, and alt levels more effectively than same, reducing the rate of preterm delivery for icp. evidence acquisition a meta-analysis of all randomized controlled trials (rcts) comparing udca, same, and combination therapy was performed. we carried out a literature search using pubmed, embase, the cochrane register of controlled trials, and the scien...
متن کاملUrsodeoxycholic Acid and S-adenosylmethionine for the Treatment of Intrahepatic Cholestasis of Pregnancy: A Meta-analysis
CONTEXT An optimal therapeutic strategy has not yet been identified for the pharmacological treatment of intrahepatic cholestasis of pregnancy (ICP). The aim of this study was to evaluate the efficacy and safety of ursodeoxycholic acid (UDCA) and S-adenosylmethionine (SAMe) in the treatment of ICP, both individually and in combination. EVIDENCE ACQUISITION A meta-analysis of all randomized co...
متن کاملEfficacy and safety of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy.
UNLABELLED Background and aims. Patients with intrahepatic cholestasis of pregnancy (ICP) benefit from ursodeoxycholic acid (UDCA) treatment. Since there is still certain reluctance to use UDCA in pregnant women, mainly due to warnings in the official SPC information in respective drug leaflets, our objective was to assess the efficacy and safety of UDCA during pregnancy. MATERIAL AND METHOD...
متن کاملIntrahepatic cholestasis of pregnancy: observational study of the treatment with low-dose ursodeoxycholic acid
BACKGROUND To exam the biochemical, obstetric management and pregnancy outcome in women with intrahepatic cholestasis of pregnancy (ICP) and treatment with ursodeoxycholic acid (UDCA). METHODS Pregnancy outcome in patients with ICP (N = 307) was studied and patients treated with UDCA (N = 208) vs. no UDCA were compared. The data of the antenatal visits, deliveries and neonatal outcome of 307 ...
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ژورنال
عنوان ژورنال: The Lancet
سال: 2019
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(19)31607-1